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Geoffrey W. Hoffmann : ウィキペディア英語版 | Geoffrey W. Hoffmann
Geoffrey W. Hoffmann, (born October 20, 1944) is an Australian-Canadian theoretical biologist. Hoffmann was a faculty member in the Department of Physics at the University of British Columbia and is currently chairman and chief scientist at Network Immunology Inc. in Vancouver, Canada. He is best known for symmetric immune network theory. == Education and early research ==
Hoffmann studied physics at the University of Melbourne then obtained a PhD (Dr. rer. nat., Technische Universität Braunschweig) as a student of Manfred Eigen for research done at the Max Planck Institute for Biophysical Chemistry in Göttingen. His initial work in theoretical biology addressed Leslie Orgel's paradox in origin of life theories. Hoffmann showed that an early sloppy translation machinery can be stable against the error catastrophe envisaged by Orgel 〔G. W. Hoffmann (1974) On the Origin of the Genetic Code and the Stability of the Translation Apparatus. J. Mol. Biol., 86, 349-362〕〔L. Orgel (1963) The Maintenance of the Accuracy of Protein Synthesis and its Relevance to Ageing. Proc. Nat. Acad. Sci. USA, 49, 517-521〕 and provided analyses of the expected occurrence of required catalytic activities and exclusion of disruptive catalytic activities.〔G. W. Hoffmann (1975) The Stochastic Theory of the Origin of the Genetic Code. Ann. Rev. Phys. Chem. 26, 123-144 (H. Eyring, Ed.)〕 These calculations support the view that the origin of replication and metabolism together is plausible.
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